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KMID : 0366919990110000248
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Sungkyun Pharmceutical Journal
1999 Volume.11 No. 0 p.248 ~ p.254
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Drug Screening for the Formulation of Topical Antiblister Preparations
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Abstract
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Abstract-The effects of various drugs on the alleviation of the symptoms of chemical burns were evaluated in mice to formulate topical antiblister preparations. After a chemical burn was induced on the mouse dorsal skin with 2-chloroethylethyl sulfide, the drug was applied on the disease site. The effectiveness of the drug was evaluated by determining blister size, necrosis score of skin and appearance of the chemical burns induced. It showed that steroids and aminoglycoside antibiotics had a tendency to protect skin cell, and antihistamines decreased the size of chemical burns. While oleaginous base resulted in deleterious effect, hydrophilic base didn´t show a significant difference on the alleviation of the chemical burn symptoms compared to the control.
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